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KMID : 1134820070360080975
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Journal of the Korean Society of Food Science and Nutrition
2007 Volume.36 No. 8 p.975 ~ p.982
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Repeated?Dose Toxicity Study of Pediococcus pentosaceus MD1, an Anti?Helicobacter pyroli Activity Lactic Acid Bacteria Isolated from Kimchi, in Rats
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Lee Jae-Joon
Lee Yu-Mi
Chang Hae-Choon
Lee Myong-Ryeol
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Abstract
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The purpose of this study was to investigate repeated?dose toxicity in male and female rats orally administered with Pediococcus pentosaceus MD1, an anti?Helicobacter pyroli producing lactic acid bacteria isolated from kimchi. Sprague?Dawley rats were divided into 4 groups, 10 animals in each group. The test article was administered once daily by gavage to rats at dose levels of 0, 500, 1,000 and 2,000 ㎎/㎏ for 4 weeks. No test article?related deaths and clinical findings in both sexes of rats during the study period were resulted. In addition, no differences were found between control and treated groups in body weight changes, food intake consumption and water consumptions. Hematological parameters, serum biochemical analysis and any other findings did not also show any significant or dose?dependent alterations. There were no alterations in absolute and relative organ weights by the administration of Pediococcus pentosaceus MD1. These results suggest that no?observed?adverse?effect level (NOAEL) of Pediococcus pentosaceus MD1 is considered to be more than 2 g/㎏ in male and female rats.
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KEYWORD
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anti-Helicobacter pyroli producing lactic acid bacteria, oral repeated-dose toxicity, rat
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